IWR-1 endo, Tankyrase inhibitor (TBI5081)

$90.00$360.00

Tankyrase inhibitor

SKU: TBI5081 Category:
SKUStock SIZE (mg) PriceQuantity
TBI5081-5MG Yes 5 MG $90.00
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TBI5081-25MG Yes 25 MG $360.00
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Description

Product Details

Formal Name: 4-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)-N-8-quinolinyl-benzamide

Molecular Formula: C25H19N3O2

Formula Weight: 409.40

CAS Number: 1127442-82-3

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to at least 10 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

 

Applications

Tankyrase inhibitor

 

Functions

A potent inhibitor of Wnt signaling (IC50=180 nM).  Inhibits zebrafish  tailfin regeneration (0.5 mM). Acts via inhibition of tankyrase and attenuates wnt/β-catenin signaling in cancer stem-like cells. Promotes self-renewal and maintains pluripotency of human embryonic stem cells. Promotes differentiation of pluripotent stem cells into cardiomyocytes.

 

Application Procedures

First dissolved in DMSO (up to at least 10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

Additional information

SIZE (mg)

25 MG, 5 MG

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