GSK4112, Rev-Erbalpha agonist (TBI5493)
$99.00 – $360.00
Rev-Erbalpha agonist
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI5493-5MG | Yes | 5 MG | $99.00 | |||
TBI5493-25MG | Yes | 25 MG | $360.00 |
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Description
Product Details
Formal Name: N-[(4-Chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl]-glycine, 1,1-dimethylethyl ester
Alternate Names: SR-6452
Molecular Formula: C18H21ClN2O4S
Formula Weight: 396.90
CAS Number: 1216744-19-2
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (50 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
Rev-Erbalpha agonist
Functions
GSK4112 is a selective Rev-Erbα agonist (EC50=250 nM). It induces circadian clock phase shifts in isolated primary lung fibroblasts as well as in lung slices (10 µM). GSK4112 showed an inhibitory effect on the amplitude of circadian oscillations and caused an arrhythmic expression of canonical clock genes. In murine RAW264 macrophages it suppressed inflammatory functions via repressing Ccl2 expression. It protected RANKL-induced bone loss via inhibition of osteoclast differentiation in vivo.
Application Procedures
First dissolved in DMSO (50 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 2 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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