FDI-6, FOXM1 inhibitor (TBI4891)

Description

Product Details

Formal Name: 3-Amino-N-(4-fluorophenyl)-6-thiophen-2-yl-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide

Alternate Names: NCGC00099374

Molecular Formula: C₁₉H₁₁F₄N₃OS₂

Formula Weight: 437.4

CAS Number: 313380-27-7

Purity: >98%

Formulation: Powder

Solubility: Soluble in DMSO (up to at least 30 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

FOXM1 inhibitor

Functions

Selectively blocks FOXM1 binding to DNA (IC₅₀ = 22.5 µM) in MCF-7 breast cancer cells and suppresses transcription of FOXM1 genes. It decreased cell proliferation, migration, and invasion in MDA-MB-231 and HS578T triple negative breast cancer cell lines. Acted synergistically with olaparib to inhibit the growth of triple negative breast and pancreatic cancer cells. It was found to induce the mRNA expression of aryl hydrocarbon receptor genes with subsequent suppression of tumorsphere formation in MCF-7 cells. FDI-6 enhanced T cell activation, supported differentiation of CD8+ cells, and T cell-mediated killing of small cell lung cancer cells.

Application Procedures

First dissolved in DMSO (up to at least 30 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

Research use only.

Additional information

Datasheet:

TBI4891_FDI-6_Datasheet

MSDS:

TBI4891_FDI-6_MSDS

Research use only.