Cisplatin, Anticancer agent (TBI2204)
$90.00 – $360.00
Anticancer agent
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI2204-100MG | Yes | 100 MG | $90.00 | |||
TBI2204-500MG | Yes | 500 MG | $360.00 |
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Description
Product Details
Formal Name: Cis-Diaminodichloroplatinum
Alternate Names: CDDP; cis-Diamineplatinum(II) dichloride
Molecular Formula: Cl2H4N2Pt
Formula Weight: 300.05
CAS Number: 15663-27-1
Purity: >98%
Formulation: powder
Solubility: Soluble in Water (up to 2.5 mg/ml with warming). Note: Compound will dissolve in DMSO, but DMSO inactivates cytotoxicity.
Storage: RT
Stability: ≥ 1 year.
Applications
Anticancer agent
Functions
Induces intra- and interstrand DNA adducts which poison topoisomerase I. Synergizes with topoisomerase I inhibitors such as topotecan. Induces apoptosis by sequential activation of caspase-8, -3 and -6 in osteosarcoma cells. Inhibits expression of X-linked inhibitor of apoptosis protein (XIAP) in human LNCaP cells. Numerous mechanisms inhibit propagation of cisplatin-induced DNA damage to signal apoptosis resulting in resistance. Clinically useful anticancer agent.
Application Procedures
First dissolved in Water (up to 2.5 mg/ml with warming), then diluted to aqueous buffer. Solutions in distilled water are not stable and must be used within 1 working day. do not store solutions.
Additional information
SIZE (mg) | 500 MG, 100 MG |
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