CDDO-Me, Nrf2 activator (TBI5449)
$108.00 – $356.00
Nrf2 activator
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI5449-5MG | Yes | 5 MG | $108.00 | |||
TBI5449-25MG | Yes | 25 MG | $356.00 |
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Description
Product Details
Formal Name: 2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid methyl ester
Alternate Names: Bardoxolone methyl; RTA 402; TP-155; CDDO-Methyl ester
Molecular Formula: C32H43NO4
Formula Weight: 505.70
CAS Number: 218600-53-4
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (25 mg/ml, warm)
Storage: -20°C
Stability: ≥ 2 years.
Applications
Nrf2 activator
Functions
Potent activator of Nrf2 target transcription via interaction with thiol groups of Keap1, an Nrf2 partner, in phase 2 response against oxidative stress. Inhibits the NF-κB pathway via inhibition of IKKα activation in vitro and reduces expression of proinflammatory cytokines in vivo. Alters tumor microenvironment causing breast tumor associated macrophages to switch from tumor-promoting to tumor-inhibiting characteristics in vitro. Reduces cancer stem cell marker expression in Ec109 and KYSE70 cells.
Application Procedures
First dissolved in DMSO (25 mg/ml, warm), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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