AI-1, Nrf2 activator (TBI1471)
$126.00 – $504.00
Nrf2 activator
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1471-5MG | Yes | 5 MG | $126.00 | |||
TBI1471-25MG | Yes | 25 MG | $504.00 |
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Description
Product Details
Formal Name: 4-Chloro-1,2-dihydro-1-methyl-2-oxo-3-quinolinecarboxylic acid ethyl ester
Molecular Formula: C13H12ClNO3
Formula Weight: 265.70
CAS Number: 75483-04-4
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 15 mg/ml).
Storage: -20°C
Stability: ≥ 2 years.
Applications
Nrf2 activator
Functions
A novel antioxidant response element (ARE) activator which activates Nrf2 by covalently modifying Keap1 (Kelch-like ECH-associated protein 1) a negative regulator of Nrf2. Modification of Cys151 of Keap1 by AI-1 disrupts the ability of Keap1 to serve as an adaptor for Cul3-Keap1 ubiquitin ligase complex, thereby stabilizing and inducing transcriptional activation of Nrf2. A useful pharmacological tool for probing the involvement of Nrf2 in cellular physiology. Cell permeable.
Application Procedures
First dissolved in DMSO (up to 15 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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