CBR-5884, Serine biosynthesis inhibitor (PHGDH inhibitor) (TBI1588)
$108.00 – $432.00
Serine biosynthesis inhibitor (PHGDH inhibitor)
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI1588-5MG | Yes | 5 MG | $108.00 | |||
TBI1588-25MG | Yes | 25 MG | $432.00 |
- Description
- Terms
- Additional information
- Documents
- Reviews (0)
Description
Product Details
Formal Name: Ethyl 5-(furan-2-carboxamido)-3-methyl-4-thiocyanatothiophene-2-carboxylate
Molecular Formula: C14H12N2O4S2
Formula Weight: 336.39
CAS Number: 681159-27-3
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 50 mg/ml), or in DMF (up to 50 mg/ml).
Storage: -20°C
Stability: ≥ 2 years.
Applications
Serine biosynthesis inhibitor (PHGDH inhibitor)
Functions
Potent and selective inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH), IC50=33 μM. The action of PHGDH is the first committed step of serine biosynthesis and certain cancer cells overexpress PHGDH. CBR-5884 inhibits serine biosynthesis in cells with no effect on two other dehydrogenases, lactate dehydrogenase and MDH1 and without general cytotoxic effects up to 40 μM. CBR-5884 is selectively toxic to tumor cells with high serine synthesis activity. A novel tool for selective inhibition of serine biosynthesis in cells which also provides further proof that PHGDH is a viable target for the development of novel anticancer agents.
Application Procedures
First dissolved in DMSO (up to 50 mg/ml), or in DMF (up to 50 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or DMF may be stored at -20°C for up to 2 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
---|
Be the first to review “CBR-5884, Serine biosynthesis inhibitor (PHGDH inhibitor) (TBI1588)”
You must be logged in to post a review.
Reviews
There are no reviews yet.