Buthionine Sulfoximine, Inhibits glutathione biosynthesis (TBI4572)
$90.00 – $162.00
Inhibits glutathione biosynthesis
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4572-100MG | Yes | 100 MG | $90.00 | |||
TBI4572-250MG | Yes | 250 MG | $162.00 |
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Description
Product Details
Formal Name: 2(S)-Amino-4-(S-butylsulfonimidoyl)butanoic acid
Molecular Formula: C8H18N2O3S
Formula Weight: 222.31
CAS Number: 5072-26-4
Purity: >98%
Formulation: powder
Solubility: Soluble in Water (up to 5 mg/ml).
Storage: -20°C
Stability: ≥ 2 years.
Applications
Inhibits glutathione biosynthesis
Functions
D,L-Buthionine sulfoximine is an irreversible inhibitor of γ-glutamylcysteine ligase (GCL). GCL is the first enzyme of the cellular glutathione biosynthetic pathway. Dysregulation of glutathione homeostasis is involved in many diseases including cancer, diabetes, neurodegenerative disorders and HIV/AIDS. Most disease states involve decreased glutathione synthesis, however, in cancer, it is increased supporting cellular proliferation and protecting cancer cells. Pharmacological inhibition of GCL has been examined as a potential cancer treatment.
Application Procedures
First dissolved in Water (up to 5 mg/ml), then diluted to aqueous buffer. Solutions are not stable and must be prepared fresh daily.
Additional information
SIZE (mg) | 250 MG, 100 MG |
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