BML283, PKM2 activator (TBI4561)
$81.00 – $342.00
PKM2 activator
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4561-5MG | Yes | 5 MG | $81.00 | |||
TBI4561-25MG | Yes | 25 MG | $342.00 |
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Description
Product Details
Formal Name: 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-ylsulfonyl)-4-(4-methoxyphenylsulfonyl)piperazine
Alternate Names: ML083
Molecular Formula: C19H22N2O7S2
Formula Weight: 454.51
CAS Number: 562867-96-3
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 10 mg/ml).
Storage: -20°C
Stability: ≥ 1 year.
Applications
PKM2 activator
Functions
BML283 is a selective activator of the Tumor Specific M2 Isoform of Pyruvate Kinase (PKM2) – AC50 = 111nM. PKM2 activity is downregulated in most cancer cells leading to a decrease in catabolic metabolism and an increase in anabolic metabolism. BML283 is an important tool for studying the effects of PKM2 and cancer metabolism.
Application Procedures
First dissolved in DMSO (up to 10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 2 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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