AAL-993, VEGFR inhibitor (TBI1034)

Description

Product Details

Formal Name: 2-[(4-Pyridyl)methyl]amino-N-[3-(trifluoromethyl)phenyl]benzamide

Molecular Formula: C₂₀H₁₆F₃N₃O

Formula Weight: 371.36

CAS Number: 269390-77-4

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 15 mg/ml).

Storage: RT

Stability: ≥ 1 year.

 

Applications

VEGFR inhibitor

 

Functions

Inhibits VEGFR-1 (IC50 = 130 nM), VEGFR-2 (IC50 = 23 nM), and VEGFR-3 (IC50 = 18 nM).   PDGFR-ß, cKit, and CSF-1R are also inhibited at higher concentrations (IC50’s 640 nM, 236 nM and 380 nM respectively).   Screening studies have shown no inhibitory activity against a range of other kinases.   X-Ray crystallography has shown that AAL-993 binds to the catalytic domain of VEGFR-2 when the protein is in an inactive conformation.   Cell permeable, active in vivo and in whole animal studies.

 

Application Procedures

First dissolved in DMSO (up to 25 mg/ml) or in Ethanol (up to 15 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Additional information

SIZE (mg)	25 MG, 5 MG

TBI1034_AAL-993