2-Chloroadenosine, A1 adenosine agonist (TBI1158)

Description

Product Details

Formal Name: 6-Amino-2-chloropurine riboside

Alternate Names: 2-CAdo; 2-CADO; 2-Cl Ado

Molecular Formula: C₁₀H₁₂ClN₅O₄

Formula Weight: 301.70

CAS Number: 146-77-0

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 30 mg/ml) or in Water (up to 7 mg/ml).

Storage: -20°C

Stability: ≥ 1 year.

 

Applications

A1 adenosine agonist

 

Functions

A metabolically stable adenosine analog that acts as an agonist at A1, A2a, and A3 adenosine receptors (Ki = 300, 80, 1900 nM). 2-Chloroadenosine is also a bidirectional substrate for equilibrative nucleoside transporter 4 (ENT4) in acidic conditions. At 100 µM, it causes accumulation of cAMP in neonatal mouse osteoblast-like cells. Reduces intracellular ATP levels through both ATP consumption and AMP deamination, and induces apoptosis in leukemic B-cells and rheumatoid fibroblasts.

 

Application Procedures

First dissolved in DMSO (up to 30 mg/ml) or in Water (up to 7 mg/ml), then diluted to aqueous buffer.

Additional information

SIZE (mg)	250 MG, 50 MG

TBI1158_2-Chloroadenosine