CRANAD-28 (TBS0017)
$65.00 – $2,990.00
Synonyms: Curcumin-derived fluorescent probe, Amyloid-β (Aβ)-targeting fluorescent probe, Near-visible fluorescent Aβ imaging probe
| SKU | Stock | SIZE (mg) | Price | Quantity | ||
|---|---|---|---|---|---|---|
| TBS0017-1 | Yes | 1 MG | $65.00 | |||
| TBS0017-10 | Yes | 10 MG | $429.00 | |||
| TBS0017-20 | Yes | 20 MG | $799.00 | |||
| TBS0017-100 | Yes | 100 MG | $2,990.00 |
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Description
Tribio CRANAD-28 is a curcumin-derived, non-conjugated fluorescent affinity probe for the detection of amyloid-β (Aβ) in vitro and in vivo. It binds with high affinity to multiple Aβ species, including Aβ40 monomers and aggregates, as well as Aβ42 monomers, dimers, and oligomers. Unlike most curcumin-based fluorescent probes, CRANAD-28 exhibits a decrease in fluorescence intensity upon binding to Aβ, providing a distinct fluorescence response for Aβ detection. CRANAD-28 has been shown to label amyloid plaques and cerebral amyloid angiopathy (CAA) in APP/PS1 mouse brain sections and in live mice, making it a valuable tool for Alzheimer’s disease research and molecular imaging.
PROPERTIES
| CAS No.: | 1623747-97-6 |
| Molecular Formula: | C27H23BF2N4O2 |
| Formula Weight: | 484.3 |
| Purity: | ≥98% |
| Form: | A crystalline solid |
| λmax: | 245, 479 nm |
| Emission: | 578 nm |
| Excitation: | 498 nm |
| Storage: | Store at -20°C, Protected from light |
| Stability | ≥ 4 years |
APPLICATION
- Detection of amyloid-β (Aβ) species in vitro and in vivo
- Fluorescence imaging of amyloid plaques and cerebral amyloid angiopathy (CAA)
- Alzheimer’s disease research
- Detection of Aβ monomers, oligomers, and aggregates
- Evaluation of Aβ-targeting therapeutics
Research use only.
Additional information
| SIZE (mg) | 1 MG, 10 MG, 20 MG, 100 MG |
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