Pictilisib (Synonyms: GDC-0941)

Pictilisib (Synonyms: GDC-0941) is a phosphatidylinositol 3-kinase (PI3K) inhibitor, free base, >99%.

CAS No.:
957054-30-7

Molecular Formula:
C₂₃H₂₇N₇O₃S₂

Molecular Weight:
513.64

Molecular Structure:

Solubility :
Soluable in DMSO

Biolagical activity:
GDC-0941 inhibits the activity of recombinant PI3K in vitro with IC50’s of 0.003 µM (P110α), 0.033 µM (P110β), 0.003 µM (P110δ), 0.075 µM (P110γ), 0.58 µM (mTOR) and 1.23 µM (DNA-PK). GDC-0941 inhibited the growth of tumor cells in vitro with IC50’s of 0.95 µM (U87MG), 0.07 µM (IGROV-1), 0.15 µM (DETROIT 562), 0.28 µM (PC3) and 0.54 µM (SKOV-3). GDC-0941 also inhibited the growth of U87 MG glioblastoma xenografts and IGROV-1 ovarian cancer xenografts in mice.

Application Target:
PI3K; Autophagy
Pathway: PI3K/Akt/mTOR; Autophagy

Storage and Shelf life:
The product is shipped on RT Store at -20°C for 2 years