Dovitinib, Receptor tyrosine kinase inhibitor (pan-specific) (TBI2129)
$135.00 – $468.00
Receptor tyrosine kinase inhibitor (pan-specific)
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI2129-5MG | Yes | 5 MG | $135.00 | |||
TBI2129-25MG | Yes | 25 MG | $468.00 |
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Description
Product Details
Formal Name: 4-Amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one
Alternate Names: TKI-258; CHIR258
Molecular Formula: C21H21FN6O
Formula Weight: 392.40
CAS Number: 405169-16-6
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 30 mg/ml).
Storage: -20°C
Stability: ≥ 2 years.
Applications
Receptor tyrosine kinase inhibitor (pan-specific)
Functions
Potent receptor tyrosine kinase inhibitor. Inhibits FLT3 (IC50 = 1 nM), c-KIT (IC50 = 2 nM), FGFR (IC50 = 8 nM), VEGFR1/2/3 (IC50 = 10 nM), PDGFRβ (IC50 = 27 nM), and CSF-1R (IC50 = 36 nM). Selectively blocks growth B9 cells transformed by wild type or activated mutant FGFR3. Induces autophagy and apoptosis in human breast cancer cells by regulating SHP-1-dependent STAT3 inhibition. Also enhances BMP-2-induced osteoblast differentiation in mouse myoblast cells. Clinically useful cancer treatment.
Application Procedures
First dissolved in DMSO (up to 30 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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