AGI-5198, R132 mutant isocitrate dehydrogenase inhibitor (TBI4599)
$72.00 – $171.00
R132 mutant isocitrate dehydrogenase inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI4599-5MG | Yes | 5 MG | $72.00 | |||
TBI4599-25MG | Yes | 25 MG | $171.00 |
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Description
Product Details
Formal Name: N-[2-(Cyclohexylamino)-1-(2-methylphenyl)-2-oxoethyl]-N-(3-fluorophenyl)-2-methyl-1H-imidazole-1-acetamide
Molecular Formula: C27H31FN4O2
Formula Weight: 462.56
CAS Number: 1355326-35-0
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 5 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
R132 mutant isocitrate dehydrogenase inhibitor
Functions
AGI-5198 is a potent (IC50 = 70 nM) inhibitor of mutant isocitrate dehydrogenase 1(IDH1). It is selective for the R132H-IDH1 mutant and does not affect wild type cells. This mutation results in loss-of-function for oxidative decarboxylation of isocitrate and gain-of-function for production of the oncometabolite R-2-hydroxyglutarate (R-2HG) form alpha-ketoglutarate (2-OG).
Application Procedures
First dissolved in DMSO (up to 10 mg/ml) or in Ethanol (up to 5 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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