EED-226, PRC2 methyltransferase inhibitor (TBI4021)
$153.00 – $513.00
PRC2 methyltransferase inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4021-5MG | Yes | 5 MG | $153.00 | |||
TBI4021-25MG | Yes | 25 MG | $513.00 |
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Description
Product Details
Formal Name: N-(Furan-2-ylmethyl)-8-(4-methylsulfonylphenyl)-[1,2,4]triazolol[4,3-c)pyrimidine-5-amine
Molecular Formula: C17H15N5O3S
Formula Weight: 369.40
CAS Number: 2083627-02-3
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
PRC2 methyltransferase inhibitor
Functions
Potent and selective allosteric inhibitor (IC50 = 23.4 nM) of the EED subunit of the methyltransferase polycomb repressive complex 2 (PRC2). Strongly inhibits proliferation of lymphoma cells with EZH2 mutations and causes shrinkage and slower tumor growth in mice in a subcutaneous xenograft model of Karpas422.
Application Procedures
First dissolved in DMSO (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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