BI-D1870, p90 Ribosomal S6 kinase inhibitor (TBI4791)
$162.00 – $585.00
p90 Ribosomal S6 kinase inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4791-5MG | Yes | 5 MG | $162.00 | |||
TBI4791-25MG | Yes | 25 MG | $585.00 |
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Description
Product Details
Formal Name: 2-(3,5-Difluoro-4-hydroxyanilino)-5,7-dimethyl-8-(3-methylbutyl)-7H-pteridin-6-one
Molecular Formula: C19H23F2N5O2
Formula Weight: 391.42
CAS Number: 501437-28-1
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 15 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
p90 Ribosomal S6 kinase inhibitor
Functions
BI-D1870 is an inhibitor of p90 ribosomal S6 kinase (RSK; IC50’s = RSK1, 31 nM; RSK2, 24 nM; RSK3, 18 nM; RSK4, 15 nM) with selectivity over other AGC kinases. It protected mice from experimental autoimmune encephalomyelitis suggesting a new strategy to treat multiple sclerosis. BI-D1870 has also been found to alter mTORC1 signaling in an RSK-independent manner. BI-D1870 induced apoptosis in oral squamous cell carcinoma cells, suppressed growth and induced apoptosis in pediatric medulloblastoma cell lines as well as sensitizing these lines to Sonic hedgehog agents, and blocked cell proliferation and protein synthesis in dual BRAF and MEK inhibitor-resistant melanoma.
Application Procedures
First dissolved in DMSO (up to 15 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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