Pifithrin α, p53 inhibitor (TBI2480)

Description

Product Details

Formal Name: 1-(4-Methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone · HBr

Alternate Names: PFT-α

Molecular Formula: C₁₆H₁₈N₂OS · HBr

Formula Weight: 367.31

CAS Number: 63208-82-2

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 25 mg/ml).

Storage: -20°C

Stability: ≥ 1 year.

 

Applications

p53 inhibitor

 

Functions

Pifithrin α (63208-82-2) is a reversible inhibitor of p53-mediated transcription and p53-dependent apoptosis.  Enhances survival after genotoxic stress and protects against chemotherapeutic side-effects in mice. Supresses self-renewal of embryonic stem cells. Pfithrin α protects against neuronal death in models of stroke and neurodegenerative disease. AhR agonist.

 

Application Procedures

First dissolved in DMSO (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

Additional information

SIZE (mg)	25 MG, 5 MG

Datasheet:

TBI2480_Pifithrin α

MSDS:

TBI2480_Pifithrin α_MSDS_2024