NSC-33994, JAK2 inhibitor (TBI1530)
$153.00 – $612.00
JAK2 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI1530-5MG | Yes | 5 MG | $153.00 | |||
TBI1530-25MG | Yes | 25 MG | $612.00 |
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Description
Product Details
Formal Name: E-4,4’-(1,2-Diethyl-1,2-ethenediyl)bis[2-[(diethylamino)methyl]phenol
Alternate Names: G6
Molecular Formula: C28H42N2O2
Formula Weight: 436.65
CAS Number: 82058-16-0
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 2 mg/ml with warming) or in Ethanol (up to 4 mg/ml with warming).
Storage: -20°C
Stability: ≥ 1 year.
Applications
JAK2 inhibitor
Functions
A remarkably potent and selective JAK2 inhibitor (IC50 = 60 nM). Displays no effect on Src and TYK2 tyrosine kinase activity at a concentration of 25 μM. Suppresses JAK2-V617F-mediated human pathological cell growth in vitro and in vivo and is concomitant with the disruption of intracellular vimentin filaments. Reduces the tumorigenic potential of T98G glioblastoma cells in vitro and in vivo.
Application Procedures
First dissolved in DMSO (up to 2 mg/ml with warming) or in Ethanol (up to 4 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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