AX-024, Inhibits TCR-dependent T cell activation (TBI4895)
$162.00 – $594.00
Inhibits TCR-dependent T cell activation
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI4895-5MG | Yes | 5 MG | $162.00 | |||
TBI4895-25MG | Yes | 25 MG | $594.00 |
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Description
Product Details
Formal Name: 1-[[4-(4-Fluorophenyl)-6-methoxy-2H-chromen-3-yl]methyl]pyrrolidine hydrochloride
Molecular Formula: C21H22FNO2·HCl
Formula Weight: 375.86
CAS Number: 1704801-24-0
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 25 mg/ml with warming) or in Water (up to 10 mg/ml with warming)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Inhibits TCR-dependent T cell activation
Functions
Potent (IC50 ~ 1 nM) and specific inhibitor of T cell antigen receptor (TCR)-dependent T cell activation. Does not inhibit B cell proliferation triggered by B cell antigen receptor (BCR), TLR4, CD40 agonists nor IL-2-dependent proliferation of T lymphoblasts. Binds to the SH3.1 domain of the adaptor protein Nck blocking its interaction with the CD3ε subunit on the T cell antigen receptor. AX-024 displays protective effects in mouse models of psoriasis, allergic asthma, and multiple sclerosis. In contrast to fingolimod, the therapeutic effect of AX-024 persisted after removal of the drug, suggesting a persistent modification of autoimmune T cells. Currently in clinical trials.
Application Procedures
First dissolved in DMSO (up to at least 25 mg/ml with warming) or in Water (up to 10 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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