2’-Deoxy-5-fluorocytidine, Irreversible DNA methyltransferase inhibitor (TBI2685)
$90.00 – $216.00
Irreversible DNA methyltransferase inhibitor
| SKU | Stock | SIZE (mg) | Price | Quantity | ||
|---|---|---|---|---|---|---|
| TBI2685-5MG | Yes | 5 MG | $90.00 | |||
| TBI2685-25MG | Yes | 25 MG | $216.00 |
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Description
Product Details
Formal Name: 5-fluoro-2’deoxycytidine
Alternate Names: FCDR; FdCyd; NSC-48006; Ro 5-1090
Molecular Formula: C9H12FN3O4
Formula Weight: 245.20
CAS Number: 10356-76-0
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 20 mg/ml).
Storage: -20°C
Stability: ≥ 2 years.
Applications
Irreversible DNA methyltransferase inhibitor
Functions
A DNA methyltransferase inhibitor currently in clinical trials for breast cancer and other solid tumors. Like 5’-Azacytidine and decitabine, 2’-Deoxy-5-fluorocytidine is a pyrimidine analog that integrates into chromatin to inhibit DNA methylation. It blocks proliferation in colon cancer-derived HCT116 cells by activating DNA response pathways. It inhibits various strains of pathogenic avian influenza viruses in vitro and in vivo.
Application Procedures
First dissolved in DMSO (up to 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 1 month.
Additional information
| SIZE (mg) | 25 MG, 5 MG |
|---|
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