TPCA-1, IKK2 inhibitor (selective) (TBI5571)
$126.00 – $360.00
IKK2 inhibitor (selective)
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI5571-5MG | Yes | 5 MG | $126.00 | |||
TBI5571-25MG | Yes | 25 MG | $360.00 |
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Description
Product Details
Formal Name: 2-[(Aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide
Molecular Formula: C12H10FN3O4S
Formula Weight: 229.30
CAS Number: 507475-17-4
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (30 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
IKK2 inhibitor (selective)
Functions
Selective inhibitor of IκB kinase 2 (IKK2) (IC50 = 17.9 nM). Inhibits production of pro-inflammatory cytokines in arthritis and other animal models of inflammation. Also attenuates NLRP3 inflammasome activation in THP-1 myeloid cells, and suppresses IL1β-induced proliferation, migration, and invasion of HeLa cells. Continuous exposure to TPCA-1 promotes expansion of hematopoietic stem/progenitor cells (HSPCs) via improved glycolysis and limited ROS production.
Application Procedures
First dissolved in DMSO (30 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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