MS-275, HDAC inhibitor (TBI2131)
$90.00 – $288.00
HDAC inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI2131-5MG | Yes | 5 MG | $90.00 | |||
TBI2131-25MG | Yes | 25 MG | $288.00 |
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Description
Product Details
Alternate Names: Entinostat
Molecular Formula: C21H20N4O3
Formula Weight: 376.42
CAS Number: 209783-80-2
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml).
Storage: -20°C
Stability: ≥ 1 year.
Applications
HDAC inhibitor
Functions
Potent HDAC inhibitor. Selective for HDAC1 (IC50 = 300 nM) over HDAC3 (IC50 = 8 µM) and HDAC8 (IC50 > 100 µM). In vivo, MS-275 has been shown to inhibit tumor growth via induction of the tumor supressors p21WAF1/CIP1 and gelsolin and to block cell proliferation in a variety of cancer cell lines. The compound has also shown significant anti-rheumatic activity in rat and mouse arthritis models.
Application Procedures
First dissolved in DMSO (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 1 week.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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