Rbin-1, Eukaryotic ribosome assembly inhibitor (TBI4606)
$90.00 – $315.00
Eukaryotic ribosome assembly inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4606-5MG | Yes | 5 MG | $90.00 | |||
TBI4606-25MG | Yes | 25 MG | $315.00 |
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Description
Product Details
Formal Name: 3-[(2-Methyl-2-propen-1-yl)sulfanyl]-5H-[1,2,4]triazino[5,6-b]indole
Molecular Formula: C13H12N4S
Formula Weight: 256.33
CAS Number: 328023-11-6
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Eukaryotic ribosome assembly inhibitor
Functions
Rbin-1 is potent (GI50 = 136 nM) and reversible inhibitor of eukaryotic ribosome assembly. The biochemical target of Rbin-1 is Midasin (Mdn1), an essential AAA+ protein. Blocking of Mdn1 by Rbin-1 inhibits the processing of pre-60S particles, important pre-ribosomal subunits produced in the nucleolus.
Application Procedures
First dissolved in DMSO (up to at least 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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