Grapiprant, EP4 receptor antagonist (TBI4006)
$153.00 – $531.00
EP4 receptor antagonist
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4006-5MG | Yes | 5 MG | $153.00 | |||
TBI4006-25MG | Yes | 25 MG | $531.00 |
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Description
Product Details
Formal Name: 1—[2-[4-(2-Ethyl-4,6-dimethylimidazo[4,5-c]pyridine-1-yl)phenyl]ethyl]-3-(4-methylphenyl)sulfonylurea
Alternate Names: CJ-023,423; ARY-007
Molecular Formula: C26H29N5O3S
Formula Weight: 491.61
CAS Number: 415903-37-6
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 10 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
EP4 receptor antagonist.
Functions
Grapiprant (415903-37-6) is a potent (Ki = 13 nM for human and 20 nM for rat) and selective prostaglandin EP4 receptor antagonist. It produces antihyperalgesic effects in animal models of pain, and has significant anti-inflammatory effects in a rat model of adjuvant-induced arthritis. EP4 receptors have been shown to be involved in PGE2 stimulation of Th1 differentiation and Th17 expansion revealing a potential role for PGE2 receptors in immunosuppression. Grapiprant/Pembrolizumab combination is in clinical trials for advanced or metastatic NSCLC adenocarcinoma.
Application Procedures
First dissolved in DMSO (up to at least 10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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