Palbociclib (PD0332991), CDK4 / CDK6 inhibitor (TBI4760)
$90.00 – $270.00
CDK4 / CDK6 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI4760-5MG | Yes | 5 MG | $90.00 | |||
TBI4760-25MG | Yes | 25 MG | $270.00 |
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Description
Product Details
Formal Name: 6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-piperazin-1-yl)pyridine-2-yl]amino]-8H-pyrido[2,3-d]pyrimidin-7-one
Alternate Names: PD-332991
Molecular Formula: C24H29N7O2
Formula Weight: 447.53
CAS Number: 571190-30-2
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 2 mg/ml with warming)
Storage: -20°C
Stability: ≥ 1 year.
Applications
CDK4 / CDK6 inhibitor
Functions
Potent and selective inhibitor of Cdk4, IC50 = 11 nM and Cdk6, IC50 = 16 nM. Inhibits phosphorylation of Rb protein and cell cycle progression through G1 in primary 5T33MM cells and sensitized these cells to killing by a proteasome inhibitor (bortezomib) in mouse models. Induces autophagy and senescence in AGS gastric cancer cells. Clinically useful breast cancer agent. Cell cycle inhibitors boost tumor immunogenicity.
Application Procedures
First dissolved in DMSO (up to 2 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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