BMS-303141, ATP citrate lyase (ACL) inhibitor (TBI1414)
$126.00 – $504.00
ATP citrate lyase (ACL) inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI1414-5MG | Yes | 5 MG | $126.00 | |||
TBI1414-25MG | Yes | 25 MG | $504.00 |
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Description
Product Details
Formal Name: 3,5-Dichloro-2-hydroxy-N-(4-methoxy[1,1’-biphenyl]-3-yl)-benzenesulfonamide
Molecular Formula: C19H15Cl2NO4S
Formula Weight: 424.30
CAS Number: 943962-47-8
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml with warming)
Storage: -20°C
Stability: ≥ 2 years.
Applications
ATP citrate lyase (ACL) inhibitor
Functions
Potent and selective ATP citrate lyase (ACL) inhibitor, IC50=0.13 μM. Inhibits lipid biosynthesis, IC50=8 μM in HepG2 cells. Reduces weight gain, lowers plasma cholesterol, triglycerides and glucose in high-fat-fed mice. A novel tool compound for exploring the potential of ACL inhibition as a target for metabolic disorders such as obesity and dyslipidemia. Impairs proliferation or induces death in androgen-depleted castration resistant prostate cancer cells. Reduces cell cycle progression in iBN cells.
Application Procedures
First dissolved in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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