Pirfenidone, Antifibrotic agent (TBI2307)
$63.00 – $198.00
Antifibrotic agent
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI2307-5MG | Yes | 5 MG | $63.00 | |||
TBI2307-25MG | Yes | 25 MG | $198.00 |
- Description
- Terms
- Additional information
- Documents
- Reviews (0)
Description
Product Details
Formal Name: 5-Methyl-1-phenyl-2(1H)-pyridinone
Molecular Formula: C12H11NO
Formula Weight: 185.23
CAS Number: 53179-13-8
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 20 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
Antifibrotic agent
Functions
Antifibrotic agent. Prevents lung fibrosis in bleomycin-induced animal models. Down-regulates bleomycin-induced overexpression of lung procollagen I and III genes. Up-regulates RGS2 (Regulator of G-protein Signaling 2) which represents a new mechanism of pirfenidone action. Inhibits fibroblast proliferation. Suppresses TNFα production at the translational level. Scavenges hydroxyl radicals and inhibits lipid peroxidation in a dose-dependent manner. Recently approved therapeutic agent for idiopathic pulmonary fibrosis. Orally active.
Application Procedures
First dissolved in DMSO (up to 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
---|
Be the first to review “Pirfenidone, Antifibrotic agent (TBI2307)”
You must be logged in to post a review.
Reviews
There are no reviews yet.