A-769662, AMPK activator (TBI1171)
$130.00 – $450.00
AMPK activator
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1171-5MG | Yes | 5 MG | $130.00 | |||
TBI1171-25MG | Yes | 25 MG | $450.00 |
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Description
Product Details
Formal Name: 4-Hydroxy-3-(2’-hydroxy-[1,1’-biphenyl]-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile
Molecular Formula: C20H12N2O3S
Formula Weight: 360.39
CAS Number: 844499-71-4
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 5 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
AMPK activator
Functions
A potent and reversible AMP-activated protein kinase (AMPK) allosteric activator. Activates AMPK by binding to the β and γ subunits and not the AMP binding site. EC50=0.8 µM for purified rat liver AMPK and inhibits fatty acid biosynthesis in rat hepatocytes IC50=3.2 µM. Inhibits the rate of whole-body fatty acid oxidation, decreases body weight gain, reduces plasma and liver triglycerides and lowers plasma glucose in ob/ob mice2. Inhibits adipocyte differentiation. Prevents transcriptional activation of Oct4 and establishes a metabolic barrier to induced pluripotent stem cell reprogramming. Synergizes with AICAR5. Cell permeable.
Application Procedures
First dissolved in DMSO (up to 30 mg/ml) or in Ethanol (up to 5 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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