VX-702, p38a MAP kinase inhibitor (TBI2181)
$72.00 – $306.00
p38a MAP kinase inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI2181-10MG | Yes | 10 MG | $72.00 | |||
TBI2181-50MG | Yes | 50 MG | $306.00 |
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Description
Product Details
Formal Name: 6-[(Aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-3-pyridinecarboxamide
Molecular Formula: C19H12F4N4O2
Formula Weight: 404.32
CAS Number: 745833-23-2
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 2 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
p38a MAP kinase inhibitor
Functions
A potent and selective inhibitor of p38 MAP kinases, p38α MAPK and p38β (KD = 3.7 and 17 nM respectively). Inhibits IL-6, IL-1β and TNFα production in LPS-primed blood. Inhibits p38 in platelets stimulated by thrombin, collagen or thromboxane agonist U-46619 at 1 μM. Provides only modest clinical efficacy in rheumatoid arthritis. Delays platelet lesions and leads to better maintenance of stored platelets.
Application Procedures
First dissolved in DMSO (up to 40 mg/ml) or in Ethanol (up to 2 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 10 MG, 50 MG |
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