ZM-447439, Aurora B kinase inhibitor (TBI1037)
$86.00 – $284.00
Aurora B kinase inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1037-5MG | Yes | 5 MG | $86.00 | |||
TBI1037-25MG | Yes | 25 MG | $284.00 |
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Description
Product Details
Formal Name: N-[4-[[6-Methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]benzamide
Molecular Formula: C29H31N5O4
Formula Weight: 513.59
CAS Number: 331771-20-1
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 25 mg/ml).
Storage: RT
Stability: ≥ 1 year.
Applications
Aurora B kinase inhibitor
Functions
ZM-447439 is a selective ATP-competitive inhibitor of Aurora kinase B1 (IC50 = 50 nM, Aur A IC50 = 1 µM, Aur C IC50 = 250 nM at physiological ATP concentrations, Ref.1 lists Aur A IC50 = 110nM and Aur B IC50 = 113nM). It did not significantly inhibit a panel of 14 other kinases including mitotic kinases CDK1 and PLK1. It prevents chromosome alignment, spindle checkpoint function and cytokinesis.
Application Procedures
First dissolved in DMSO (up to 50 mg/ml) or in Ethanol (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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