WP1066, JAK/STAT3 inhibitor (TBI4831)
$142.00 – $531.00
JAK/STAT3 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4831-10MG | Yes | 10 MG | $142.00 | |||
TBI4831-50MG | Yes | 50 MG | $531.00 |
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Description
Product Details
Formal Name: (E)-3-(6-Pyridin-2-yl)-2-cyano-N-[(1S)-1-phenylethyl]prop-2-enamide
Molecular Formula: C18H14BrN3O
Formula Weight: 356.22
CAS Number: 857064-38-1
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
JAK/STAT3 inhibitor
Functions
WP1066 (857064-38-1) is an inhibitor of the JAK2/STAT3 pathway as well as STAT5 and AKT. It downregulated Bcl-XL, Mcl-1, and c-myc while activating Bax and inducing apoptosis. Active against human malignant glioma U87-mg(IC50 = 5.6µM) and U373-mg(IC50 = 3.7µM) cells. Enhances T-cell cytotoxicity via inhibition of regulatory T-cells. WP1066 abrogated PD-L1 expression in lymphoma cell lines.
Application Procedures
First dissolved in DMSO (up to at least 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 10 MG, 50 MG |
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