Veliparib 2HCl (ABT-888), PARP 1&2 inhibitor (TBI2419)
$90.00 – $252.00
PARP 1&2 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI2419-5MG | Yes | 5 MG | $90.00 | |||
TBI2419-25MG | Yes | 25 MG | $252.00 |
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Description
Product Details
Formal Name: 2-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-7-carboxamide, dihydrochloride
Alternate Names: ABT-888
Molecular Formula: C13H16N4O • 2HCl
Formula Weight: 317.20
CAS Number: 912445-05-7
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 30 mg/ml) or in Water (up to 40 mg/ml).
Storage: -20°C
Stability: ≥ 2 years.
Applications
PARP 1&2 inhibitor
Functions
PanPARP inhibitor (Ki = 5.2 PARP1 and 2.9 nM PARP2). Restores sensitivity to DNA alkylator/methylator temozolomide in glioma cells and xenografts, and enhances radiotherapy sensitivity in endometrial carcinoma cells. Also improves sensitivity to DNA replication inhibitor cisplatin in human oral carcinoma cells.
Application Procedures
First dissolved in DMSO (up to 30 mg/ml) or in Water (up to 40 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or water may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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