UNC-2170 HCl, Methyl-lysine binding protein inhibitor (TBI1558)
$162.00 – $648.00
Methyl-lysine binding protein inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1558-5MG | Yes | 5 MG | $162.00 | |||
TBI1558-25MG | Yes | 25 MG | $648.00 |
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Description
Product Details
Formal Name: 3-Bromo-N-(3-(tert-butylamino)propyl)benzamide, hydrochloride
Molecular Formula: C14H21BrN2O • HCl
Formula Weight: 349.69
CAS Number: 1648707-58-7
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 40 mg/ml) or in Water (up to 50 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Methyl-lysine binding protein inhibitor
Functions
UNC-2170, identified by screening, was found to be a μM ligand for 53BP1 which also demonstrated at least 17-fold selectivity for 53BP1 over other methyl-lysine binding proteins. The DNA damage response protein 53BP1 utilizes its tandem tudor domain to recognize dimethylated lysine 20 on histone (H4K20me2), a modification associated with double-strand DNA breaks. UNC-2170 functions as a 53BP1 antagonist in cell lysates and suppresses class switch recombination in whole cells, a process requiring a functioning 53BP1 tudor domain.
Application Procedures
First dissolved in DMSO (up to 40 mg/ml) or in Water (up to 50 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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