TTNPB, Retinoic RAR agonist (TBI2517)
$115.00 – $396.00
Retinoic RAR agonist
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI2517-5MG | Yes | 5 MG | $115.00 | |||
TBI2517-25MG | Yes | 25 MG | $396.00 |
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Description
Product Details
Formal Name: 4-[(E)-2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl]benzoic acid
Alternate Names: Ro 13-7410; AGN-191183; Arotinoid acid
Molecular Formula: C24H28O2
Formula Weight: 348.50
CAS Number: 71441-28-6
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 4 mg/ml).
Storage: -20°C
Stability: ≥ 2 years.
Applications
Retinoic RAR agonist
Functions
A highly potent and selective retinoic acid analog acting as an RAR agonist (EC50 = 21, 4 and 2.4 nM for RARα, RARβ and RARγ respectively). TTNPB has been extensively used in stem cell differentiation protocols. It enhances reprogramming efficiency in chemically induced pluripotent stem cells. Chondrocytes are robustly induced from human pluripotent stem cells by treatment with CHIR99021 and TTNPB. TTNPB alone, efficiently converts primary adult mouse fibroblasts into dermal papilla cell-like cells. Can be used in combination with other small molecules for induction of mouse totipotent stem cells.
Application Procedures
First dissolved in DMSO (up to 4 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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