Trifluorothymidine, Thymidylate synthase inhibitor; Anti cancer agent (TBI1283)
$81.00 – $297.00
Thymidylate synthase inhibitor; Anti cancer agent
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1283-50MG | Yes | 50 MG | $81.00 | |||
TBI1283-250MG | Yes | 250 MG | $297.00 |
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Description
Product Details
Formal Name: 2’-Deoxy-5-trifluoromethyluridine
Alternate Names: α,α,α-Trifluorothymidine; Trifluorothymine deoxyriboside; Trifluridine; TFT
Molecular Formula: C10H11F3N2O5
Formula Weight: 296.20
CAS Number: 70-00-8
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml) or in Water (up to 14 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Thymidylate synthase inhibitor; Anti cancer agent
Functions
An analog of thymidine which inhibits thymidylate synthase possesses antiviral and anticancer activity. After phosphorylation by thymidine kinase, it is incorporated into DNA where it induces DNA-damage and interferes with repair enzymes. Enhances frame shift insertion and deletion in CRISPR genome editing in pluripotent stem cells.
Application Procedures
First dissolved in DMSO (up to 25 mg/ml) or in Water (up to 14 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 250 MG, 50 MG |
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