Nilvadipine, Syk inhibitor & Ca2+ channel blocker (TBI3035)

Description

Product Details

Formal Name: 2-Cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-(1-methylethyl) ester

Alternate Names: FR34235

Molecular Formula: C₁₉H₁₉N₃O₆

Formula Weight: 385.38

CAS Number: 75530-68-6

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 15 mg/ml).

Storage: -20°C

Stability: ≥ 1 year.

 

Applications

Syk inhibitor & Ca2+ channel blocker

 

Functions

A novel DHP L-type Ca2+ channel blocker that also inhibits Syk. Blocks Aβ production, APPβ secretion and reduces BACE-1 expression in CHO cells over-expressing Aβ in vitro. Enhances clearance of Aβ across the blood brain barrier in vivo. Reduces brain Aβ levels in a mouse tauopathy model. Clinically useful antihypertensive agent. Has been shown to prevent cognitive decline in some clinical trials. Produces a protective effect on glutamate neurotoxicity in retinal ganglion cells, an effect not shared by other L-type Ca2+ channel blockers such as nifedipine and diltiazem.

 

Application Procedures

First dissolved in DMSO (up to 25 mg/ml) or in Ethanol (up to 15 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Additional information

SIZE (mg)	250 MG, 50 MG

TBI3035_Nilvadipine