TH10785, OGG1 activator (TBI5698)
$117.00 – $468.00
OGG1 activator
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI5698-5MG | Yes | 5 MG | $117.00 | |||
TBI5698-25MG | Yes | 25 MG | $468.00 |
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Description
Product Details
Formal Name: N-Cyclohexyl-2-cyclopropyl-4-quinazolinamine
Molecular Formula: C17H21N3
Formula Weight: 267.40
CAS Number: 1002801-51-5
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (50 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
OGG1 activator
Functions
An 8-oxo guanine DNA glycosylase 1 (OGG1) activator. Oxidative DNA damage is recognized by OGG1 which then excises 8-oxoguanine, leaving a substrate for apurinic endonuclease 1 (APE1) and initiating DNA repair. TH10785 binds to Phe319 and Gly42 of OGG1 increasing it catalytic activity 10-fold and generating a previously undescribed β,δ-lyase enzymatic function. TH10785 increases OGG1 recruitment to and repair of oxidative DNA damage. Increased repair of oxidative DNA damage by small molecules may have therapeutic applications in various diseases and aging.
Application Procedures
First dissolved in DMSO (50 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 2 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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