TC-E 5003, Arginine methyl transferase 1 (PRMT1) inhibitor (TBI1499)

Description

Product Details

Formal Name: N,N’-(Sulfonyldi-4,1-phenylene)bis(2-chloroacetamide)

Molecular Formula: C₁₆H₁₄Cl₂N₂O₄S

Formula Weight: 401.26

CAS Number: 17328-16-4

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 50 mg/ml).

Storage: -20°C

Stability: ≥ 2 years.

 

Applications

Arginine methyl transferase 1 (PRMT1) inhibitor

 

Functions

Selective protein arginine methyltransferase 1 (PRMT1) inhibitor, IC50 = 1.5 μM. Displays no activity against CARM1 and Set7/9 methyltransferases. Inhibits growth of MCF7a breast cancer cells and LNCaP prostate cancer cells. Blocks androgen-induced gene expression in LNCaP cells.

 

Application Procedures

First dissolved in DMSO (up to 50 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 1 month.

Additional information

SIZE (mg)	250 MG, 50 MG

TBI1499_TC-E 5003