Syrosingopine, MCT4 inhibitor (TBI4688)

Description

Product Details

Formal Name: Methyl (1R,15S,17R,18R,19S,20S)-17-(4-ethoxycarbonyloxy-3,5-dimethoxybenzoyl)oxy-6,18-dimethoxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate

Molecular Formula: C₃₅H₄₂N₂O₁₁

Formula Weight: 666.7

CAS Number: 84-36-6

Purity: >98%

Formulation: Powder

Solubility: Soluble in DMSO (up to at least 25 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

MCT4 inhibitor

Functions

A reserpine derivative that is an inhibitor of monocarboxylate transporter 4 (IC₅₀ MCT4 = 40 nM; IC₅₀ MCT1 = 2.5 µM). It prevents lactate and H⁺ efflux. Elicits synthetic lethality in cancer cells in combination with metformin via NAD+ depletion leading to glycolytic blockade and cell death. It displays anticancer activity in several cancer models including leukemia, breast, NSCLC, and glioblastoma. Syrosingopine was originally used to treat hypertension via its antinoradrenergic effects.

Application Procedures

First dissolved in DMSO (up to at least 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

Research use only.

Additional information

Datasheet:

TBI4688_Syrosingopine_Datasheet

MSDS:

TBI4688_Syrosingopine_MSDS

Research use only.