STF-083010, IRE1 inhibitor; UPR inhibitor (TBI1510)
$90.00 – $306.00
IRE1 inhibitor; UPR inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1510-5MG | Yes | 5 MG | $90.00 | |||
TBI1510-25MG | Yes | 25 MG | $306.00 |
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Description
Product Details
Formal Name: N-[(2-Hydroxy-1-naphthalenyl)methylene]-2-thiophenesulfonamide
Molecular Formula: C15H11NO3S2
Formula Weight: 317.39
CAS Number: 307543-71-1
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 30 mg/ml)
Storage: RT
Stability: ≥ 1 year.
Applications
IRE1 inhibitor; UPR inhibitor
Functions
A novel small molecule inhibitor of IRE1. It inhibits IRE1 endonuclease activity but not its kinase activity after endoplasmic reticulum stress. It displays significant antimyeloma activity in model human MM xenografts. Induces apoptosis in pancreatic cancer cells and displays growth inhibition in a clonogenic growth assay in soft agar as well as in a xenograft in vivo model of pancreatic cancer. Active in vivo.
Application Procedures
First dissolved in DMSO (up to 30 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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