Stattic, STAT3 inhibitor (TBI2524)
$81.00 – $288.00
STAT3 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI2524-10MG | Yes | 10 MG | $81.00 | |||
TBI2524-50MG | Yes | 50 MG | $288.00 |
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Description
Product Details
Formal Name: 6-Nitrobenzo[b]thiophene 1,1-dioxide
Molecular Formula: C8H5NO4S
Formula Weight: 211.20
CAS Number: 19983-44-9
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 1 mg/ml).
Storage: -20°C
Stability: ≥ 2 years.
Applications
STAT3 inhibitor
Functions
STAT3 inhibitor. Inhibits binding of tyrosine-phosphorylated peptides to STAT3 SH2 domain and inhibiting STAT3 activation, dimerization and nuclear translocation. Displays selectivity over STAT1, STAT5, c-Myc/Max, Jun/Jun and Lck. Induces apoptosis in STAT3-dependent cancer cell lines. Alkyates four cysteine residues on STAT3. Exhibits potent antitumor activity. Protects against angiotensin II-induced vascular dysfunction and hypertension. An extremely useful tool to probe involvement of STAT3 in cellular signaling.
Application Procedures
First dissolved in DMSO (up to 10 mg/ml) or in Ethanol (up to 1 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 10 MG, 50 MG |
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