SRPIN340, SRPK inhibitor (TBI1500)
$122.00 – $490.00
SRPK inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1500-5MG | Yes | 5 MG | $122.00 | |||
TBI1500-25MG | Yes | 25 MG | $490.00 |
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Description
Product Details
Formal Name: N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamide
Molecular Formula: C18H18F3N3O
Formula Weight: 349.35
CAS Number: 218156-96-8
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 25 mg/ml).
Storage: -20°C
Stability: ≥ 1 year.
Applications
SRPK inhibitor
Functions
Selective serine arginine protein kinase (SRPK) 1 inhibitor (Ki = 0.89 μM). Inhibits SRPK2 at higher concentrations. Does not significantly inhibit other SRPKs such as CLK1 and CLK4, or other classes of SR kinases. Inhibits viral replication by inhibition of host SR protein kinases. Modulates VEGF splicing to reduce pathological neovascularization in a rat model of retinopathy and controls VEGF-mediated tumor angiogenesis in xenografts.
Application Procedures
First dissolved in DMSO (up to 40 mg/ml) or in Ethanol (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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