Spautin-1, USP10&13 inhibitor; autophagy inhibitor (TBI1367)

Description

Product Details

Formal Name: 6-Fluoro-N[(4-fluorophenyl)methyl]-4-quinazolinamine

Molecular Formula: C₁₅H₁₁F₂N₃

Formula Weight: 271.27

CAS Number: 122888-28-7

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 15 mg/ml with warming).

Storage: -20°C

Stability: ≥ 1 year.

 

Applications

USP10&13 inhibitor; autophagy inhibitor

 

Functions

A specific and potent autophagy inhibitor. Spautin-1 promotes the degradation of Vps34 PI3 kinase complexes by inhibiting two ubiquitin-specific proteases USP10 and USP13 which target the Beclin-1 subunit of Vps34 complexes. Deranges dengue virion maturation. Inhibits autophagy in a Beclin-1 independent manner in primary epithelial ovarian cancer cells. Selectively induces cell death of mutant p53-expressing cancer cell lines under confluency. Cell permeable.

 

Application Procedures

First dissolved in DMSO (up to 50 mg/ml) or in Ethanol (up to 15 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

Additional information

SIZE (mg)	25 MG, 5 MG

TBI1367_Spautin-1