SB-525334, ALK5 (TGF bR1) inhibitor (TBI2983)
$108.00 – $396.00
ALK5 (TGF bR1) inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI2983-5MG | Yes | 5 MG | $108.00 | |||
TBI2983-25MG | Yes | 25 MG | $396.00 |
- Description
- Terms
- Additional information
- Documents
- Reviews (0)
Description
Product Details
Formal Name: 6-[2-(1,1-Dimethylethyl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-4-yl]quinoxaline
Molecular Formula: C21H21N5
Formula Weight: 343.42
CAS Number: 356559-20-1
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 30 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
ALK5 (TGF bR1) inhibitor
Functions
Potent and selective inhibitor of the transforming growth factor beta 1 receptor, activin receptor-like kinase (ALK5), IC50 = 14.3 nM and ALK4 (IC50 = 58.5 nM) with no activity at ALK2, 3 and 61. Blocks fibrosis markers and renal injury in the puromycin-induced nephritis model. It causes significant attenuation in Smad2/3 nuclear translocation, decrease in CTGF-expressing cells, myofibroblast proliferation and type 1 collagen deposition resulting in an overall attenuation in bleomycin-induced pulmonary fibrosis. Sensitizes drug-resistant pancreatic cancer cells to gemcitabine. Cell permeable and active in vivo.
Application Procedures
First dissolved in DMSO (up to 30 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
---|
Be the first to review “SB-525334, ALK5 (TGF bR1) inhibitor (TBI2983)”
You must be logged in to post a review.
Reviews
There are no reviews yet.