Rocaglamide, TNFa inhibitor (TBI2484)
$108.00 – $432.00
TNFa inhibitor
SKU | Stock | SIZE | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI2484-100UG | Yes | 100 µg | $108.00 | |||
TBI2484-500UG | Yes | 500 µg | $432.00 |
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Description
Product Details
Alternate Names: RocA
Molecular Formula: C29H31NO7
Formula Weight: 505.60
CAS Number: 84573-16-0
Purity: >97%
Formulation: powder
Solubility: Soluble in DMSO
Storage: -20°C
Stability: ≥ 2 years.
Applications
TNFa inhibitor
Functions
Potent inhibitor of NFκB in T-lymphocytes with almost complete inhibition at 200 nM. Completely inhibits IL-4 and IFN-γ production and suppresses IL-2 and TNF-α production at 50 nM in T-cells, without inhibiting AP-1 and NF-κB. Immunosuppresive activity is due to inhibition of cytokine gene expression via blocking NF-AT activity. Has anti-cancer properties via various pathways including ERK inhibition, ATM/ATR-Chk1/Chk2 activation, and p38 and JNK activation.
Application Procedures
First dissolved in DMSO, then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.
Additional information
SIZE | 100 µg, 500 µg |
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