RO-3306, Selective CDK1 inhibitor (TBI4126)
$117.00 – $387.00
Selective CDK1 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4126-5MG | Yes | 5 MG | $117.00 | |||
TBI4126-25MG | Yes | 25 MG | $387.00 |
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Description
Product Details
Formal Name: 5-(6-Quinolinylmethylene)-2-[(2-thienylmethyl)amino]-4(5H)-thiazolone
Molecular Formula: C18H13N3OS2
Formula Weight: 351.45
CAS Number: 872573-93-8
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 15 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Selective CDK1 inhibitor
Functions
RO-3306 is a selective inhibitor of CDK1 (IC50 = 35 nM versus CDK2 IC50 = 340nM). It induces G2/M phase cell cycle arrest and apoptosis. Inhibition of CDK1 with RO-3306 has been shown to have synergistic effects with PARP inhibitors in treating various breast cancers. It has also been demonstrated to overcome apoptotic resistance in BRAFV600E human colorectal cancer cells.
Application Procedures
First dissolved in DMSO (up to 15 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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