RI-1, RAD51 inhibitor (TBI1617)

Description

Product Details

Formal Name: 3-Chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)-1H-pyrrole-2,5-dione

Molecular Formula: C₁₄H₁₁Cl₃N₂O₃

Formula Weight: 361.61

CAS Number: 415713-60-9

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 45 mg/ml) or in Ethanol (up to 10 mg/ml with warming).

Storage: -20°C

Stability: ≥ 1 year.

Applications

RAD51 inhibitor

Functions

RI-1 is a potent and selective inhibitor of RAD51 (IC50 = 5-30 μM), a highly conserved protein that catalyzes DNA repair via homologous recombination. It specifically reduces gene conversion in human cells and stimulates single strand annealing. It covalently binds to Cys319 on the surface of RAD51 and disrupts protein-protein interaction. It potentiates the effect of DNA-damaging agents on tumor cells and is a novel tool for studying DNA repair in cells. Potentiates the killing of glioblastoma cells by ionizing radiation and alkylating drugs.

Application Procedures

First dissolved in DMSO (up to 45 mg/ml) or in Ethanol (up to 10 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.

Research use only.

Additional information

Datasheet:

TBI1617_RI-1

MSDS:

TBI1617_RI-1_MSDS_2024

Research use only.