RepSox, TGFβR-1 / ALK5 inhibitor (TBI4546)
$117.00 – $450.00
TGFβR-1 / ALK5 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4546-5MG | Yes | 5 MG | $117.00 | |||
TBI4546-25MG | Yes | 25 MG | $450.00 |
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Description
Product Details
Formal Name: 2-(3-(6-Methylpyridine-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine
Alternate Names: E-616452; SNJ 2511; 616452
Molecular Formula: C17H13N5
Formula Weight: 287.30
CAS Number: 446859-33-2
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 10 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
TGFβR-1 / ALK5 inhibitor
Functions
RepSox is a potent inhibitor of the TGF-β type I receptor (ALK5), IC50 ALK5 auto-P= 4 nM and IC50 TGF-β cellular assay = 23 nM. RepSox can replace Sox2 in reprogramming adult cells into pluripotent stem cells via induction of Nanog transcription. It was able to convert astrocytes into neuronal cells as part of a small molecule cocktail (along with valproic acid and CHIR99021).
Application Procedures
First dissolved in DMSO (up to 25 mg/ml) or in Ethanol (up to 10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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