Preladenant, Adenosine A2A receptor antagonist (TBI4102)
$117.00 – $405.00
Adenosine A2A receptor antagonist
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4102-5MG | Yes | 5 MG | $117.00 | |||
TBI4102-25MG | Yes | 25 MG | $405.00 |
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Description
Product Details
Formal Name: 4-(Furan-2-yl)-10-[2-[4-[4-(2-methoxyethoxy)phenyl]piperazin-1-yl]ethyl]-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7,11-pentaen-7-amine
Alternate Names: SCH 420814
Molecular Formula: C25H29N9O3
Formula Weight: 503.57
CAS Number: 377727-87-2
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (5 mg/ml with warming)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Adenosine A2A receptor antagonist
Functions
Preladenant is a potent (Ki = 1.1nM) and selective (>1000-fold over other adenosine receptors) adenosine A2A antagonist. It has shown efficacy in rodent and primate models of Parkinsons disease without inducing dyskinesias and displays antidepressant effects. It has been shown that activation of the adenosine A2A receptor blocks the activation of immune cells and increases the number of regulatory T-cells. Currently in clinical trials as combination therapy with pembrolizumab.
Application Procedures
First dissolved in DMSO (5 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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